Angioplastia de tronco de coronária esquerda não protegido: relato de dois casos / Unprotected left main coronary artery angioplasty: report on two cases

A intervenção coronariana percutânea em tronco de coronária esquerda (TCE) é um grande desafio que, nestes últimos anos com o uso de stents farmacológicos, tem ampliado a sua realização. As angioplastias com implante de stents apresentam resultados técnicos imediatos próximos a 100%, com taxas de mortalidade por todas as causas semelhantes aos resultados cirúrgicos, e essa segurança e novos dispositivos permitem que sejam tratados casos mais complexos, como as lesões de TCE.Relatam-se neste artigo dois casos de angioplastias deTCE não protegido, em pacientes com contra indicação de revascularização cirúrgica, realizadas com implantes de stents convencionais (hospital público), com excelente resultado imediato.

Percutaneous intervention in the left main coronary artery (LMCA) is still a great challenge. However, with the advent of drug-eluting stents, it has become more common over the past few years. Angioplasties with stent implantation present immediate technical outcomes at close to 100% success, with mortality rates from all causes similar to surgical approaches. This safety and new devices allow more complex cases to be treated, such as LMCA lesions. This report addresses two cases of unprotected left main coronary artery angioplasty inpatients counter-indicated for surgical coronary artery bypass graft (CABG) surgery, performed in Brazilian government hospitals using bare metal stents, with excellent immediate outcomes.

Study of acute hepatotoxicity of Equisetum arvense L. in rats.

PURPOSE: To evaluate the acute hepatotoxicity of Equisentum arvense L. in rats. METHODS: Fifty Wistar rats were used, these being divided in four groups, one being the control (receiving only water) and the other groups receiving graded doses of Equisentum arvense L. (30, 50, and 100mg/kg respectively) for 14 days. Blood samples were obtained to determine TGO, TGP, FA, DHL and GT-gamma activities. After that, hepatic tissue samples were collected for the anatomopathologic analysis. RESULTS: The anatomopathologic exam of the hepatic tissue showed organ with preserved lobular structure. In the same way, there was no significant change in the seric activities of the hepatic enzymes when compared to control group. CONCLUSION: The oral treatment with graded doses of Equisentum arvense L. was not able to produce hepatic changes. Further studies are necessary to evaluate the chronic hepatotoxicity of Equisentum arvense L. in rats.

Study of acute hepatotoxicity of Equisetum arvense L. in rats / Estudo da hepatotoxicidade aguda da Equisetum arvense L. em ratos

PURPOSE: To evaluate the acute hepatotoxicity of Equisentum arvense L. in rats. METHODS: Fifty Wistar rats were used, these being divided in four groups, one being the control (receiving only water) and the other groups receiving graded doses of Equisentum arvense L. (30, 50, and 100mg/kg respectively) for 14 days. Blood samples were obtained to determine TGO, TGP, FA, DHL and GT-gamma activities. After that, hepatic tissue samples were collected for the anatomopathologic analysis. RESULTS: The anatomopathologic exam of the hepatic tissue showed organ with preserved lobular structure. In the same way, there was no significant change in the seric activities of the hepatic enzymes when compared to control group. CONCLUSION: The oral treatment with graded doses of Equisentum arvense L. was not able to produce hepatic changes. Further studies are necessary to evaluate the chronic hepatotoxicity of Equisentum arvense L. in rats.

OBJETIVO: Investigar a hepatotoxicidade aguda da Equisetum arvense L. em ratos. MÉTODOS: foram utilizados 50 ratos Wistar, os quais foram divididos em quatro grupos, sendo um controle (recebendo apenas água) e os outros grupos recebendo doses crescentes de cavalinha (30, 50 e 100mg/Kg, respectivamente) por 14 dias. Foram coletadas amostras de sangue para determinação da atividade sérica de TGO, TGP, FA, DHL e gama-GT. Em seguida, foram obtidas amostras de tecido hepático para análise anatomopatológica. RESULTADOS: O exame anatomopatológico de tecido hepático demonstrou órgão com estrutura lobular preservada. Da mesma forma, não houve alteração significativa na atividade sérica das enzimas hepáticas, quando comparado ao grupo controle. CONCLUSÃO: O tratamento com doses crescentes de Equisetum arvense L., não induziu hepatotoxicidade aguda em ratos. Novos estudos são necessários para avaliar a hepatoxicidade crônica de Equisetum arvense L. em ratos.